Orbis Biosciences®’ technologies provide innovative formulation and manufacturing for modified release of oral and injectable pharmaceutical products. Adare Pharma Solutions retains all institutional knowledge and intellectual property to offer the Orbis Biosciences® technologies to the World.
The Orbis Biosciences® platforms produce uniform microspheres and microcapsules with narrow size distribution and precise control over particle structure. These platforms are elegant and robust solutions with countless applications. With unprecedented control of particle size there are new ways to improve and differentiate products, including their delivery, efficacy, and safety.
In the subcategory technology, called Stratµm®, these particle size control approaches are applied to biodegradable polymers for injectable applications. In the subcategory Optimµm®, the same approaches are used to create lipid-based powders for solid oral applications. Unisun® is a separate Orbis Biosciences® platform dedicated to body surface delivery of therapeutics (tympanic membranes, skin, etc.). The compatibility with a wide range of excipients and particle sizes enables unique functionality and product opportunities for creating first-in-class prescription formulations or matching complex modified release profiles of over-the-counter products.
The Orbis Biosciences® technologies were developed with industry in mind for manufacturing and for development services. It delivers on the promise of precision microparticles at a previously unachievable scale.
The platform technology includes three subcategories: Stratµm®, Optimµm®, and Unisun®.
- Particle size down to 10µm with a ±5% deviation from the mean diameter
- Analogous to emulsion processes
- Requires lyophilization
- Compatible with PLGAs, PLAs, PCLs, PCPHs, alginates, gelatins and other biopolymers
- Good for injectable small molecules, proteins, peptides, vaccines and heat-labile molecules
- Particle sizes down to 75µm with Span values as low as 0.40
- Analogous to spray congealing
- No drying step or coating required
- Compatible with waxes, lipids, stearates, gelatins
- Good for oral small molecules, nutraceuticals, agricultural applications, flavorings and heat stable molecules
- Combines Stratµm® microspheres with a film forming agent, or film-forming agent alone
- Film-forming agent uses a non-irritating aqueous base
- Film-forming agent dries quickly on warm biological surfaces
- Can be used to inject and set up highly concentrated depots of a drug
- Good for small molecules, proteins, peptides and vaccines
Speak With An Expert
Nathan Dormer
Director, Drug Product Development
Nathan Dormer, Ph.D., is the Director of Drug Product Development at Adare Pharma Solutions and is responsible for pharmaceutical development activities at Adare’s Lenexa, KS and Philadelphia, PA facilities, where he supports a team of formulation scientists and analysts. He is a pharmaceutical scientist and bioengineer by training, with more than 16 years of experience developing microsphere-based solid oral and parenteral/implantable dosage forms in academic, innovator, and CDMO settings. Dr. Dormer earned his B.S. in Chemical Engineering and his Ph.D. (w/Honors) in Bioengineering from The University of Kansas while receiving NIH-sponsored Pharmaceutical Biotech Training.
