A controlled-release technology providing a number of benefits for your drug product
Diffucaps controls drug delivery and optimizes release profiles
- Adjustable dosage strength and dissolution profile to achieve the desired in vivo pharmacokinetic profile
- Available as a capsule, orally disintegrating tablet, rapidly disintegrating tablet, or as a sprinkle
- Enhances drug solubility in sections of the gastrointestinal tract through combined use with other Adare technologies
- Reduces gastric mucosal irritation and food effect
Multiparticulate system with release-controlling polymers
- One or more functional polymer membranes are applied to a drug core resulting in a small, multi-layered bead
- Solubility-modulation technology can be used to create an optimal pH
- Organic acid layer is placed underneath the drug layer, while the alkaline buffer is placed over the drug layer
- Coatings ensure that the individual layers are not depleted until release of the drug is complete
Solid-Solution or Solid-Dispersion for Enhanced Solubility
An alternative to our standard Diffucaps® system, Solid-Solution or Solid-Dispersion Diffucaps® enhance solubility by preserving a drug’s amorphous form. Additional functional polymers can achieve extended release profiles.
Speak With An Expert
Nathan Dormer
Director, Drug Product Development
Nathan Dormer, Ph.D., is the Senior Director of Drug Product Development & Site Leader at Adare Pharma Solutions and is responsible for pharmaceutical development activities at Adare’s facilities, supporting a team of formulation scientists and analysts. He is a pharmaceutical scientist and bioengineer by training, with more than 16 years of experience developing microsphere-based solid oral and parenteral/implantable dosage forms in academic, innovator, and CDMO settings. Dr. Dormer earned his B.S. in Chemical Engineering and his Ph.D. (w/Honors) in Bioengineering from The University of Kansas while receiving NIH-sponsored Pharmaceutical Biotech Training.